Scientists researching Labrador retrievers have identified multiple genes linked to obesity in dogs, with findings that extend to human obesity as well. The study, published in the journal Science, presents a breakthrough in understanding how genetics influence weight gain and appetite regulation across species. Obesity remains a pressing global health issue, with the World Health Organization estimating that more than 1 billion people worldwide are classified as overweight or obese. This epidemic is mirrored in the canine population, where studies indicate that between 40 and 60 percent of companion dogs are overweight or obese. Excess weight in dogs, much like in humans, increases the risk of serious health conditions, including diabetes, heart disease, and joint disorders.

The research team from the University of Cambridge pinpointed DENND1B as the gene most strongly associated with obesity in Labrador retrievers, a gene also found in humans and linked to obesity. Beyond DENND1B, researchers identified four additional genes linked to canine obesity, all of which have direct human counterparts. While genetics play a significant role in obesity risk, the study found that strict control over a dog’s diet and exercise could prevent obesity even in genetically predisposed individuals. The findings highlight the importance of understanding genetic predispositions in managing weight in both humans and dogs.