While Domino's in the US does not offer vegan cheese or plant-based pepperoni, it is still possible to order a plant-based pizza using the chain's vegan-friendly options. In the UK, Domino's previously had a variety of vegan pizzas to choose from, but the options have been reduced. In the US, there is hope for future plant-based options, as the former CEO mentioned testing plant-based sausage crumbles in 2020.

Other pizza chains in the US have dabbled with plant-based toppings, such as Pizza Hut offering Beyond Meat sausage and Little Caesars with plant-based pepperoni. Despite Domino's not having a designated vegan pizza on its menu, customers can still build a vegan pizza by choosing a vegan crust, sauce, and vegetable toppings. Customizing a vegan pizza with options like mushrooms, black olives, and jalapeños can provide a satisfying meal for those looking for plant-based options.