Vegan actor Woody Harrelson made an appearance on the American YouTube talk show Hot Ones, swapping chicken wings for cauliflower as he tackled the spicy hot sauce challenge. Known for his outspoken advocacy for animals and a plant-based diet, Harrelson has been vegan for over 30 years and has praised the benefits of a mostly raw, whole food plant-based lifestyle for giving him energy. Hot Ones has featured a meat-free or plant-based option since at least 2016, with some guests choosing vegan alternatives like seitan, tempeh, and cauliflower.

During the challenge, Harrelson visibly struggled with the spicier wings, but managed to finish the challenge with the help of some non-dairy milk. Despite the heat, he ended the episode by performing a magic trick. Other non-vegan guests, such as Lady Gaga, John Oliver, Lizzo, and Florence Pugh, have also chosen plant-based wings on the show. Animal rights charity PETA has urged Hot Ones to adopt an all-vegan menu, with race car driver Lewis Hamilton suggesting that they should "just do the vegan ones" to save countless chickens.